This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Homology and Alignment
Gene homologs of HLA-DQA1
Homologous genes are those that are derived from a common ancestor, and may have evolved independently from one another in various species. I used Homologene to identify homologs of the HLA-DQA1 gene in different organisms. This resource was very easy to use and also provided a link to the individual protein and DNA sequences in Entrez for each organism. While HLA-DQA1 was found to have a few homologs in different species, I specifically chose to highlight the chimpanzee, dog, mouse, and rat.
Pan troglodytes (chimpanzee)
Gene name: HLA-DQA1
Accession number: NC_006473.2
Canis lupus familiaris (domestic dog)
Gene name: HLA-DQA1
Accession number: NC_006594.2
Gene name: HLA-DQA1
Accession number: NC_006473.2
Canis lupus familiaris (domestic dog)
Gene name: HLA-DQA1
Accession number: NC_006594.2
Mus musculus (mouse)
Gene name: H2-Aa
Accession number: NC_000083.5
Rattus norvegicus (rat)
Gene name: RT1-Ba
Accession number: NC_005119.2
Gene name: H2-Aa
Accession number: NC_000083.5
Rattus norvegicus (rat)
Gene name: RT1-Ba
Accession number: NC_005119.2
Homolog gene sequences
The file below shows the Homo sapiens gene sequence compared with gene sequences of the 4 homologs.
| gene_homologues.docx |
Gene Alignments
Due to the length of the sequence, MUSLCE was the only program able to produce an alignment of the HLA-DQA1 gene sequence.
| muscle_gene_alignment.docx |
