This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
HLA-DQA1 protein interactions
HLA-DQA1 protein
Predicted interacting proteins
Analysis
Using STRING, I was able to obtain the images found above. The protein interaction web shows all of the proteins that are predicted to interact with the HLA-DQA1 protein in Homo sapiens. Each of the proteins in the interaction web are then described further in the chart provided, giving the name and a brief cellular role. The proteins in this network have a score of 0.800 or higher.
HLA-DQB1, CD4, and CD74 all interact directly with HLA-DQA1. HLA-DQB1 exists as part of a heterodimer with HLA-DQA1, functioning critically in the immune system. CD4 functions as an accessory protein to HLA-DQA1 and T-cell receptor interaction. CD74 plays a critical role in MHC class II antigen processing by stabilizing the alpha/beta heterodimer and directing transport of the heterodimer out of the endoplasmic reticulum. These cellular roles are interesting because they all confirm the role that HLA-DQA1 plays in the immune system, presenting peptides to T-cells, which then mediate the toxic immune response involved in celiac disease.
HLA-DQB1, CD4, and CD74 all interact directly with HLA-DQA1. HLA-DQB1 exists as part of a heterodimer with HLA-DQA1, functioning critically in the immune system. CD4 functions as an accessory protein to HLA-DQA1 and T-cell receptor interaction. CD74 plays a critical role in MHC class II antigen processing by stabilizing the alpha/beta heterodimer and directing transport of the heterodimer out of the endoplasmic reticulum. These cellular roles are interesting because they all confirm the role that HLA-DQA1 plays in the immune system, presenting peptides to T-cells, which then mediate the toxic immune response involved in celiac disease.
References
- Images from STRING 8.3. HLA-DQA1 evidence map. Retrieved from: http://stringdb.org/newstring_cgi/show_network_section.pltaskId=8jlOaZSDtoSa&interactive=yes&advanced_menu=_unassigned&network_flavor=evidence
